CBD & Depression

In Condition, News by MW


With a lot of things going on, the ups and downs of life, and working hard to make ends meet, most people do spend some time alone in their thoughts. The body is designed to take on a lot of work and also designed to adapt to new situations. Just like a machine that switches itself off when overheated for a time out, our bodies react the same when we are stressed.

When we face certain conditions like loss, self-esteem issues, sickness, or rejection; It is natural to fall into a feeling of sadness and droll over the situation. It then becomes a problem when this feeling lasts longer than usual.

We can describe depression as a disease because during such times, we are not able to be productive or think normal, we may not have appetite to eat, or have any interest for other important things in our lives. Good a thing, it is not an incurable disease, there have been many solutions and therapies in place for the cure of depression, which also includes the use of CBD products. Before we talk about the use of CBD for depression, we would take some time to elaborate more on the symptoms of depression and some facts about it. 

Depression is one of the most common mental ailments and disorders; the health world has grouped it into three major types which are: classic depression, dysthymia and bipolar or seasonal disorder. 

The world health organization gave an estimate that in twenty years, depression will be the second highest cause of death. 

Another point worth addressing is the diagnosing of depression through its symptoms, when you are able to diagnose and detect your problems, then you are able to figure out how to go about solving them. Most people who get killed by depression never had it diagnosed or treated which could be a reason why they may opt or consider suicide because depression on a greater scale eats you up such that you feel life is meaningless. 

Listed here are some of the signs and symptoms you should look out for to spot depression:

-Sadness; sometimes unnecessary sadness that never gets away.

-A sudden loss of interest without an explanation, for to the things you loved doing.

-Hard to concentrate and low energy to carry out anything.

-Decision making becomes an issue.

-Affects your eating habit and appetite; even when you try to eat, there is a problem with digestion.

-You may end up sleeping excessively or most of the time not find sleep at all (insomnia).

-The intense feeling of hopelessness.

-Sexual problems, lack of interest even when with an intimate partner.



-In extreme cases, thoughts of death, self-mutilation and attempted suicide. 

CBD and Depression

Different research has found that the endocannabinoid system is associated with mood regulation. A system dysfunction, which leads to a reduction in the concentration of cannabinoids was associated with depression and mood disorders. This dysfunction is probably caused by chronic stress, according to a study that found that exposure to different forms of stress significantly reduced the concentration of endocannabinoids in women diagnosed with Depression.

These findings suggest that cannabinoids, such as THC (tetrahydrocannabinol) and CBD (cannabidiol) found in cannabis, influence the endocannabinoid system and may help regulate the drug, offering therapeutic potential. Cannabinoids have been shown to promote neurogenesis in the hippocampus, suggesting that they could produce anxiolytic and antidepressant effects.

Studies have confirmed that both THC and CBD offer sedative, antipsychotic and antidepressant effects. A clinical study with animals found that administration of cannabinoids was able to normalize endocannabinoid function and consequently stabilize mood and relieve depression.

Several animal studies have demonstrated the antidepressant and anxiolytic effects (antianxiety) of CBD. In another human study, administration of CBD before or after individuals were conditioned to a colored box with electric shocks generated a reduction in automatic contextual response, suggesting that CBD could be effective in the treatment of anxiety disorders. More recently, in an animal study, it has been found that CBD rapidly generates antidepressant and anxiolytic effects. Evidence indicates that it is the interaction of CBD with the neuroreceptor 5-HT1A that causes these effects

It has been found that THC alters the response to negative emotions and images. In one study, people with THC in the bloodstream experienced a reduction in the negative propensity for emotional processing. A human study found that THC and CBD are effective in reducing response to frightening facial expressions.

Cannabis can also help manage health risks associated with depression, as it is linked to an increased risk of developing cardiovascular disease and higher resting systolic blood pressure. However, one study found that administration of cannabinoids in women diagnosed with depression was effective in controlling high blood pressure.

In addition, a 2012 study found that suicide rates overall decreased by 5% in states where there is legislation regulating the use of medical marijuana shortly after its implementation. Changes in cannabis-related laws have led to an 11% decrease in the suicide rate among men between 20 and 29 years of age and 9% between 20 and 39, with a drastic decrease in young people between the ages of 15 and 19.

Recent studies on the effects of cannabis in depression

-Several animal studies have shown that CBD has antidepressant properties

-Cannabidiol antidepressant and anxiolytic effects: a chemical compound of Cannabis sativa.

-It has been found that CBD offers antidepressant effects comparable to the drug imipramine.

-Antidepressant effects of cannabidiol in mice: possible involvement of 5-HT 1A receptors